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在妊娠期应用过己烯雌酚的患者所生产的女孩,在青春期及青春后期可发生某种继发疾病。作者通过对62例曾在妊娠期应用己烯雌酚治疗的妇女所生育的女孩进行随访与调查,发现其中有些女孩患有妇科疾患而需治疗,因此作者对其中15例(年龄在15—23岁,平均年龄18岁)进行详细检查,部份病例并作了活体检查。在15例患者中发生阴道粘膜罩者10例,杨梅样宫颈6例,宫颈鸡冠样增生者5例,宫颈内肿瘤样形成者4例,颗粒状阴道,阴道腺病及腺癌各1例,在此15例中检查无病
Girls who have been treated with diethylstilbestrol during pregnancy have some secondary disease during adolescence and later in life. The authors followed up and surveyed 62 girls who had been treated with diethylstilbestrol during pregnancy and found that some of them had gynecological problems and were treated. Therefore, the authors evaluated 15 of them (15-23 years old, mean Age 18 years) to conduct a detailed examination, in some cases and made a living examination. In 15 patients, 10 cases occurred vaginal mucosal mask, Myrica-like cervix in 6 cases, 5 cases of cervical chicken-like hyperplasia, 4 cases of cervical tumor-like formation, granular vaginal, vaginal adenosis and adenocarcinoma in 1 case, In this 15 cases check disease-free