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目的探讨中药与西药所致药物性肝损伤的临床对比分析。方法选取2013年6月至2014年10月于青岛市市立医院就医的110例药物性肝损伤患者作为研究对象,根据不同病因,将其分为中药组(46例)和西药组(64例)。采集所有患者空腹血液标本,检测其丙氨酸转氨酶(ALT)、谷氨酰转移酶(GGT)、总胆红素(TBIL)水平,同时统计两组患者用药情况以及肝脏损伤程度。结果中药组患者均为口服给药,而西药组64例患者中,口服18例,静脉给药46例;中药组中,使用消核片患者例数最多,而西药组中,使用抗结核药物患者例数最多;中药组中患者的ALT水平显著高于西药组,差异有统计学意义(P<0.05);中药组患者重度肝损伤比例明显高于西药组,差异有统计学意义(P<0.05)。结论西药与中药在导致肝损伤方面存在一定差异,中药引起的肝损伤比西药引起的肝损伤更严重。
Objective To investigate the clinical comparative analysis of drug-induced liver injury caused by traditional Chinese medicine and western medicine. Methods Totally 110 patients with drug-induced liver injury who were admitted to Qingdao Municipal Hospital from June 2013 to October 2014 were selected as the study objects. According to their different causes, they were divided into two groups: the traditional Chinese medicine group (46 cases) and the western medicine group (64 cases) . The fasting blood samples of all patients were collected to detect the levels of ALT, GGT and TBIL. The medication status and the degree of liver damage in both groups were also calculated. Results The patients in the TCM group were orally administered, whereas in the western medicine group, 18 were oral and 46 were intravenously administered in 64 patients. In the traditional Chinese medicine group, the patients with ablative tablets had the highest number of cases, while in the western medicine group, anti-tuberculosis drugs The number of patients was the highest; the level of ALT in Chinese medicine group was significantly higher than that in western medicine group (P <0.05); the proportion of severe liver injury in Chinese medicine group was significantly higher than that in western medicine group (P < 0.05). Conclusion Western medicine and Chinese medicine have some differences in liver injury. Chinese medicine-induced liver injury is more serious than western medicine-induced liver injury.