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原发性肝细胞癌(下称肝癌)是全世界最常见的恶性肿瘤之一,肝癌的外科治疗近几十年来已有长足进步,手术切除的5年生存率已由10%上升到40%左右,然而术后5年无瘤生存率仍只有16%～27.4%,肿瘤术后复发和转移仍是进一步提高疗效的主要障碍。目前认为肝癌术后复发与肿瘤、宿主及治疗等多方面因素有关,近年来预测肝癌复发的分子生物学标志物进展较快,本文就目前影响肝癌术后复发临床病理学因素研究现状综述如下。1 宿主因素1.1 病人的年龄和性别女性患者的术后复发率低,肿瘤包膜多完整,瘤细胞的侵袭性低,性激素受体差异性表达可能与此有关。年青肝癌患者术后复发可能性大,可能与HBsAg
Primary hepatocellular carcinoma (hereinafter referred to as liver cancer) is one of the most common malignancies in the world. Surgical treatment of liver cancer has made great strides in recent decades, and the 5-year survival rate of resection has risen from 10% to 40% , However, the 5-year disease-free survival rate after operation is still only 16% to 27.4%. The recurrence and metastasis of the tumor are still the major obstacles to further improve the curative effect. Now that the recurrence of liver cancer and tumor, host and treatment and many other factors in recent years to predict the recurrence of liver cancer molecular biology markers progress rapidly in this paper on the impact of recurrence of liver cancer clinicopathological factors are summarized below. 1 host factors 1.1 The patient’s age and gender Female patients with low recurrence rate, complete tumor capsule, tumor cell invasion is low, sex hormone receptor differential expression may be related to this. Young patients with liver cancer recurrence after the possibility of large, probably with HBsAg