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目的:比较腔隙性(LI)与非腔隙性(NLI)脑梗塞患者血压变化,评价血压与腔隙性脑梗塞的相关性。方法:选取在我院住院治疗的249例急性脑梗塞患者,根据不同亚型将患者分为腔隙性脑梗塞组(LI组,n=187)与非腔隙性脑梗塞组(NLI组,n=62),比较两组患者血压差异,采用线性相关分析与cox相关分析评估血压与脑梗塞及其危险因素的相关性。结果:LI组患者入院3天收缩压、舒张压显著高于NLI患者组,差异有统计学意义(分别P=0.003,P=0.009);线性回归分析表明,入院时收缩压、入院第3天收缩压、入院第3天舒张压与LI显著相关(均P<0.05);cox单因素与多因素分析表明,入院第3天收缩压与LI显著相关(分别P=0.009与P=0.006),与其他协变量不相关(均P>0.05)。而患者出院时血压与m RS或NIHSS不相关(分别P=0.788和P=0.898)。结论:与相同严重程度NLI患者比较,LI患者高血压与LI独立相关。LI患者血压显著高于NLI患者,二者差异虽与临床疾病严重程度无关,但很可能是患者发生急性脑梗塞的根本原因。
Objective: To compare the changes of blood pressure in patients with lacunar infarction (LI) and non-lacunar infarcts (NLI) to evaluate the correlation between blood pressure and lacunar infarction. Methods: A total of 249 patients with acute cerebral infarction who were hospitalized in our hospital were divided into lacunar infarction group (LI group, n = 187) and non-lacunar infarction group (NLI group, n = 62). The differences of blood pressure between the two groups were compared. The correlation between blood pressure and cerebral infarction and its risk factors was evaluated by linear correlation analysis and cox correlation analysis. Results: The systolic blood pressure and diastolic blood pressure in LI group were significantly higher than those in NLI group on the 3rd day after admission (P = 0.003, P = 0.009, respectively). Linear regression analysis showed that systolic blood pressure Systolic blood pressure and diastolic blood pressure were significantly correlated with LI on the third day after admission (all P <0.05). Univariate and multivariate analyzes showed that systolic blood pressure was significantly correlated with LI (P = 0.009 and P = 0.006, respectively) Not related to other covariates (all P> 0.05). Blood pressure was not related to m RS or NIHSS at discharge (P = 0.788 and P = 0.898, respectively). CONCLUSIONS: Compared with patients with the same severity of NLI, hypertension in patients with LI is independently associated with LI. LI patients with blood pressure was significantly higher than NLI patients, although the difference between the two has nothing to do with the severity of clinical disease, but may be the root cause of patients with acute cerebral infarction.