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最小模型是模拟内分泌代谢系统中葡萄糖-胰岛素相互作用的数学模型,它与多样本静脉葡萄糖耐量试验相结合,定量地评估胰岛素敏感性、葡萄糖效能。这些指数对临床与基础研究、糖尿病流行病研究都具有重要的作用。本文对最小模型的发展、与之相关的数学模型及其应用方面进行了综述。
The smallest model is a mathematical model that mimics the glucose-insulin interaction in the endocrine-metabolic system and is used in combination with multiple-sample intravenous glucose tolerance tests to quantitatively assess insulin sensitivity and glucose performance. These indices play an important role in clinical and basic research as well as in the study of the epidemic of diabetes. In this paper, the development of the smallest model, the related mathematical model and its application are reviewed.