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目的:探讨神经γ突触核蛋白(SNCG)在子宫颈癌、宫颈不典型增生及正常组织中的表达。方法:用免疫组化SP法检测73例子宫颈癌、36例宫颈不典型增生和18例慢性宫颈炎组织中SNCG的表达情况。结果:宫颈癌组织SNCG的阳性率为65.8%(48/73),而宫颈不典型增生SNCG的阳性率为36.1%(13/36),正常组织中未见SNCG的表达。在低分化、中等分化及高分化的宫颈癌组织中,SNCG的阳性率分别为89.3%(25/28)、66.7%(20/30)及20.0%(3/15)。肿瘤组织分化程度越低,SNCG的阳性率越高;SNCG在Ⅰ期肿瘤组织中表达阳性率为35.0%(7/20),Ⅱ期为66.7%(20/30),Ⅲ期为91.3%(21/23),肿瘤组织临床分期越晚SNCG的阳性率越高。结论:SNCG蛋白在宫颈癌的发生、发展过程中起着重要的作用,肿瘤分期越晚阳性率越高,SNCG有望成为新的宫颈癌的肿瘤标志,为预后判断和制定相应的治疗方案提供依据。
Objective: To investigate the expression of neural gamma-synuclein (SNCG) in cervical cancer, cervical dysplasia and normal tissues. Methods: The expressions of SNCG in 73 cases of cervical cancer, 36 cases of cervical atypical hyperplasia and 18 cases of chronic cervicitis were detected by immunohistochemical SP method. Results: The positive rate of SNCG in cervical cancer was 65.8% (48/73), while the positive rate of SNCG in cervical dysplasia was 36.1% (13/36). No SNCG expression was detected in normal tissues. In poorly differentiated, moderately differentiated and well-differentiated cervical cancer, the positive rates of SNCG were 89.3% (25/28), 66.7% (20/30) and 20.0% (3/15), respectively. The positive rate of SNCG in the stage Ⅰ tumor was 35.0% (7/20), 66.7% (20/30) in stage Ⅱ and 91.3% in stage Ⅲ 21/23). The later the clinical stage of tumor was, the higher the positive rate of SNCG was. Conclusion: SNCG protein plays an important role in the occurrence and development of cervical cancer. The higher the positive rate of SNCG is, the higher the positive rate of SNCG is. It will be the tumor marker of new cervical cancer and provide the basis for prognosis judgment and formulating the corresponding treatment plan .