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研制出了一种用于环境刺激感应型控制释放的分子识别型微囊。该微囊具有核壳结构多孔膜、并在膜孔中接枝有作为分子识别开关的聚 [异丙基丙烯酰胺 -共 - (苯并 - 1 8-冠 - 6 -丙烯酰胺 ) ] (poly(NIPAM co BCAm) )线形链。采用了界面聚合法制备核壳结构多孔微囊膜 ,并采用了等离子体接枝填孔聚合法在膜孔内接枝poly(NIPAM co BCAm)线形链。囊内溶质从该微囊中的释放特性明显受环境溶液中Ba2 + 离子的存在与否状态所控制。当环境溶液中没有BaCl2 分子存在时 ,由于微囊膜孔内接枝的poly(NIPAM co BCAm)聚合物链呈收缩状态而使膜孔开启 ,所以释放速度快 ;相反 ,当环境溶液中有BaCl2 分子存在时 ,微囊膜孔内接枝的poly(NIPAM co BCAm)链呈膨胀状态 ,于是膜孔关闭 ,从而导致释放速度变得很慢。该具有poly(NIPAM co BCAm)接枝开关的微囊的分子识别刺激感应释放特性显示出了良好的可逆性和可重复性
A molecular recognition microcapsule has been developed for environmental stimulus-responsive controlled release. The microcapsules have a core-shell porous membrane and are grafted with poly [poly (isopropylacrylamide-co- (8-crown-6-acrylamide)] as a molecular recognition switch (NIPAM co BCAm) linear chain. The interfacial polymerization was used to prepare the porous microcapsule membrane with core-shell structure. The poly (NIPAM co BCAm) linear chains were grafted onto the membrane pores by plasma grafting and pore-filling polymerization. The release characteristics of intracapsular solutes from the microcapsules are significantly controlled by the presence or absence of Ba2 + ions in the environmental solution. When there is no BaCl2 molecule in the environment solution, the release rate is faster due to the shrinkage of the poly (NIPAM co BCAm) polymer chain grafted in the microencapsule pores, which results in the faster release rate. On the contrary, when BaCl2 In the presence of molecules, the poly (NIPAM co BCAm) chains grafted in the microcapsule pores are swollen and the membrane pores are closed, resulting in a very slow release rate. The molecular recognition of the microcapsules with poly (NIPAM co BCAm) grafting switches stimulated the induction of release characteristics showing good reversibility and repeatability