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目的探讨阿奇霉素序贯疗法治疗小儿社区获得性肺炎临床效果。方法社区获得性肺炎患儿380例随机分为观察组和对照组各190例,对照组应用阿奇霉素[10mg/(kg.d)]加入葡萄糖溶液中静脉滴注,1次/d,持续静脉用药;观察组上述剂量阿奇霉素,静脉给药3~5 d,体温正常、外周血白细胞正常、病情稳定改为门诊口服阿奇霉素等。结果对照组临床总有效率97.9%与观察组的98.4%比较差异无统计学意义(P>0.05);对照组平均住院(11.82±2.34)d长于观察组(5.34±1.42)d;对照组药物不良反应29例高于观察组的5例(P<0.05)。结论阿奇霉素序贯疗法治疗小儿社区获得性肺炎安全、有效、经济实用,临床应用具有可行性。
Objective To investigate the clinical effect of sequential therapy of azithromycin on children with community-acquired pneumonia. Methods 380 cases of children with community-acquired pneumonia were randomly divided into observation group and control group of 190 cases, the control group with azithromycin [10mg / (kg · d)] added to glucose solution intravenous drip, 1 / d, continuous intravenous ; Observation group the above dose of azithromycin, intravenous administration of 3 ~ 5 d, normal body temperature, normal peripheral white blood cells, stable condition changed to oral azithromycin and so on. Results The average clinical effective rate was 97.9% in the control group compared with 98.4% in the observation group (P> 0.05). The average length of stay in the control group (11.82 ± 2.34) d was longer than that in the observation group (5.34 ± 1.42) d. 29 cases of adverse reactions were higher than the observation group in 5 cases (P <0.05). Conclusion Sequential azithromycin treatment of children with community-acquired pneumonia is safe, effective, economical and practical, clinical application is feasible.