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人体是否易于感染疟疾、发病和死亡受宿主基因型、寄生虫毒力和周围因素包括疟疾特异免疫力的影响。免疫应答本身又取决于宿主基因和环境作用的配合。宿主基因型对潜在免疫反应谱的限制程度可能影响感染的结果并对疫苗设计有一定意义。本文综述了主要组织相容性复合物(MHC)相关和无关基因与人对轻症、或重症疟疾易感性,疟原虫抗原免疫应答的调控以及疫苗的研制等方面所起的作用。
Whether or not the human body is susceptible to malaria, morbidity and mortality are affected by host genotypes, parasiticidal virulence and surrounding factors, including malaria-specific immunity. The immune response itself depends on the cooperation of the host genes and the environment. The extent to which host genotypes limit potential immune responses may affect the outcome of the infection and have some implications for vaccine design. This article reviews the roles played by MHC-associated and unrelated genes in human susceptibility to mild or severe malaria, the regulation of the immune response to the Plasmodium antigen, and the development of vaccines.