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树突状细胞(dendritic cell,DC)是目前已知体内最强的抗原提呈细胞(APC),其在肿瘤免疫中具有重要的作用。DC的靶向抗肿瘤治疗成为当今肿瘤免疫治疗的研究热点。本文就DC的抗肿瘤机制、DC基因修饰策略及DC疫苗的临床治疗进展进行综述。
Dendritic cells (DCs) are the strongest antigen-presenting cells (APCs) in the body and they play an important role in tumor immunity. Targeted anti-tumor therapy of DC has become a hot research topic in tumor immunotherapy. In this paper, the anti-tumor mechanism of DC, DC gene modification strategy and the progress of clinical treatment of DC vaccine are reviewed.