广西地区抗疟组于1969年,在中草药抗疟筛选实验中,发现小檗科植物南天竹(Nandinadomestica Thunb.)叶水煎,按生药15g/kg,经口灌胃,一日2次,连续3日,对鼠疟原虫(Plasmodium berghei)有90%以上的抑制率,但在狗的实验中,表现出抽搐的毒性。为了提高药效,降低毒性,广西化工研究所对南天竹叶进行抗疟有效成分的提取,证明主为普鲁托品(protopine),其后又进行了化学结构改造, Antimalarial Group in Guangxi Province In 1969, in the anti-malaria screening test of Chinese herbal medicine, it was found that the leaves of Nandinadomestica Thunb., A species of Berberidaceae, were decocted and decocted by oral administration of 15g / kg of crude drug twice daily for continuous On the 3rd, there was over 90% inhibition of Plasmodium berghei, but convulsive toxicity in dogs. In order to improve the efficacy and reduce the toxicity, Guangxi Chemical Industry Research Institute of southern bamboo leaves for anti-malarial active ingredients extracted to prove the main protopine (protopine), and then the chemical structure transformation,