论文部分内容阅读
目的评估三维适形放疗辅助DDP同期化疗治疗宫颈癌复发患者的临床疗效与毒副作用。方法卵巢癌治疗后复发患者36例,以直线加速器6mv-x行三维适形放疗,单次剂量2～2.5gy,1次/d,每周5次,总剂量为55～60Gy,平均剂量为57.5Gy。同步辅助DDP化疗,给予DDP30～40mg/m2。结果阴道出血缓解率为100%,腰腿疼痛缓解率为100%,患侧下肢水肿缓解率为78%,肿瘤治疗有效率(CR+PR)为66.7%,1年和3年生存率为36%和12%,中位生存时间为19个月。近期并发症:消化道反应的发生率为15.3%,骨髓抑制的(Ⅰ-Ⅱ度)发生率为83.3%,放射性肠炎的发生率为7.8%,放射性膀胱炎的发生率为2.9%。远期并发症:放射性肠炎的发生率为5.6%。放射性膀胱炎的发生率为4.6%。结论三维适形放射治疗辅助DDP同期化疗治疗卵巢癌复发患者疗效较好,毒副作用可耐受,不失为有效的治疗。
Objective To evaluate the clinical efficacy and side effects of three-dimensional conformal radiotherapy and concurrent DDP chemotherapy in the treatment of recurrent cervical cancer. Methods Thirty-six patients with recurrence of ovarian cancer were treated with linear accelerator 6mv-x three-dimensional conformal radiotherapy at a single dose of 2 ~ 2.5gy once a day for 5 times a week for a total dose of 55-60 Gy with an average dose of 57.5Gy. Synchronization of DDP chemotherapy, given DDP30 ~ 40mg / m2. Results The response rate of vaginal bleeding was 100%, the pain relief rate of lumbar and leg was 100%, the relief rate of ipsilateral lower extremity edema was 78%, the effective rate of tumor treatment (CR + PR) was 66.7%, and the 1-year and 3-year survival rate was 36 % And 12%, the median survival time of 19 months. Recent complications: The incidence of digestive tract reactions was 15.3%, bone marrow suppression (Ⅰ-Ⅱ degree) was 83.3%, radiation enteritis was 7.8%, the incidence of radiation cystitis was 2.9%. Long-term complications: The incidence of radiation enteritis is 5.6%. The incidence of radiation cystitis was 4.6%. Conclusion Three-dimensional conformal radiotherapy adjuvant DDP concurrent chemotherapy for the treatment of patients with ovarian cancer recurrence better efficacy, side effects can be tolerated, after all, an effective treatment.