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目的：研究妊高征患者的胎盘组织超微结构病理学改变与胎盘血中脂质过氧化物（ＬＰＯ）水平的关系。方法：用电镜观察胎盘组织的超微结构，并通过测定血清ＬＰＯ产物－丙二醛的水平计算ＬＰＯ水平。结果：妊高征患者血清ＬＰＯ水平明显高于对照组，其胎盘组织病理学改变非常明显，并与ＬＰＯ水平密切相关。结论：妊高征患者的胎盘组织损伤越严重，ＬＰＯ水平越高，血清ＬＰＯ水平升高可能是妊高征发病原因之一。
OBJECTIVE: To study the relationship between the pathological changes of placental ultrastructure and the levels of lipid peroxides (LPO) in the patients with pregnancy induced hypertension (PIH). Methods: The ultrastructure of placenta was observed by electron microscopy and LPO level was calculated by measuring the level of serum LPO product, malondialdehyde. Results: Serum LPO level in patients with PIH was significantly higher than that in control group. The histopathological changes of placenta were obvious and closely related to LPO level. Conclusion: The placental tissue injury is more serious in patients with PIH. The higher the level of LPO and the increase of serum LPO levels may be one of the causes of PIH.