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柯延宁是尼古丁代谢的主要降解产物,它的血清半衰期约17小时,而尼古丁的血清半衰期为2小时。测量柯延宁水平能提供吸食烟草的敏感指标。为推动流行病学的研究发展,需要关于血清、唾液和尿中柯延宁测量的相应敏感性的比较数据。98名24～66岁对象:其中28名不吸烟者不与吸烟者住在一起,也不在吸烟的环境中工作。20名被动吸烟者不吸烟同吸烟者住一起(8人),或者工作在吸烟的办公室或房间内(12人)。49名主动吸烟者每日吸烟3～50支。吸烟者在未获得标本前不得吸烟。柯延宁用无光式气液色谱法测定。结果,少数不吸烟者血清或唾液中检出柯延宁。所有49名被动吸烟者血清和45名主动吸烟者唾液中也检出柯延灯。每日吸烟≤10支者血清加唾液中柯延宁平均水平低于每日吸烟>10支者。
Ke Yaning is a major degradation of nicotine metabolism, its serum half-life of about 17 hours, while the serum half-life of nicotine for 2 hours. Measuring Cohenning levels can provide sensitive indicators of tobacco consumption. To facilitate the development of epidemiological research, comparative data are needed on the corresponding sensitivities measured in Coenzyme in serum, saliva and urine. 98 subjects aged 24 to 66 years: 28 of them non-smokers do not live with smokers and do not work in a smoking environment. Twenty passive smokers did not smoke with the smoker (8) or in a smoking office or room (12). 49 active smokers smoke 3 to 50 cigarettes a day. Smokers must not smoke before obtaining specimens. Ke Yanning with matte gas-liquid chromatography. As a result, a small number of non-smokers detected in the serum or saliva Kemainen. All 49 passive smoker sera and 45 active smokers were also detected in the saliva. The average level of coryn-nium in serum plus saliva with ≤10 cigarettes per day of smoking was lower than 10 cigarettes smoked per day.