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近20余年来,新的抗心律失常药不断涌现,使一些顽固的或威胁生命的心律失常得以控制。兹仅将近年常用的数种新药作一介绍,以供临床参考。一、乙胺碘呋酮(Amiodarone)1974年Rosenbaum 等首先用于治疗预激综合征伴阵发性心动过速的患者,疗效显著。本药为苯并呋喃衍生物,通过对α-和β-肾上腺素能受体的非竞争性抑制而降低儿茶酚胺的交感兴奋作用,属第Ⅳ类抗心律失
In the past two decades or more, new antiarrhythmic drugs have been emerging to control some of the most stubborn or life-threatening arrhythmias. It is only introduced in recent years several kinds of new drugs commonly used for clinical reference. First, amiodarone (Amiodarone) In 1974 Rosenbaum other first used to treat WPW syndrome with paroxysmal tachycardia in patients with significant effect. The drug is a benzofuran derivative, which inhibits the sympathetic excitability of catecholamines by noncompetitive inhibition of α- and β-adrenergic receptors and is a Class IV antiarrhythmic