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目的:探讨妊娠中期血、尿β-h CG水平与胎盘功能障碍的关系。方法:以45例胎盘功能障碍孕妇为观察组,同期45例正常晚期孕妇为对照组,回顾分析该90例孕妇妊娠中期血、尿β-h CG、血清AFP和血清CA125。结果:3级胎盘和胎儿窘迫孕妇血β-h CG值为(1.94±0.52)和(2.75±0.45)nmol/L,尿液β-h CG标准浓度为(287.9±58.4)和(305.2±55.1)ng/mg,血清AFP值为(255.73±91.84)和(275.17±94.33)ng/ml,血清CA125值为(41.91±14.82)和(47.24±17.32)μ/ml,均明显高于正常孕妇的(0.91±0.33)nmol/L、(146.5±47.2)ng/mg、(112.93±39.68)ng/ml和(24.23±9.14)μ/ml(P值均<0.05)。血β-h CG诊断与血清AFP诊断比较具有统计学差异(P<0.05);血、尿β-h CG诊断分别与血清AFP诊断、血清CA125诊断比较具有统计学差异(P<0.05)。结论:妊娠中期血、尿β-h CG水平和血清AFP、CA125水平可准确反映胎盘功能障碍的存在,且血、尿β-h CG的诊断更为准确。
Objective: To investigate the relationship between β-h CG levels and placental dysfunction in the second trimester of pregnancy. Methods: Forty-five pregnant women with placental dysfunction were enrolled as observation group and 45 normal pregnant women as control group during the same period. The blood and urinary β-h CG, serum AFP and serum CA125 were analyzed retrospectively in 90 pregnant women. Results: The blood β-h CG values of (1.94 ± 0.52) and (2.75 ± 0.45) nmol / L in pregnant women with grade 3 placenta and fetal distress were (287.9 ± 58.4) and (305.2 ± 55.1) (255.73 ± 91.84) and (275.17 ± 94.33) ng / ml, serum CA125 values were (41.91 ± 14.82) and (47.24 ± 17.32) μ / ml respectively, which were significantly higher than those of normal pregnant women (0.91 ± 0.33) nmol / L, (146.5 ± 47.2) ng / mg, (112.93 ± 39.68) ng / ml and (24.23 ± 9.14) μ / ml respectively. There was a significant difference between the serum β-h CG diagnosis and the serum AFP diagnosis (P <0.05). The blood and urine β-h CG diagnosis were statistically different from the serum AFP diagnosis and the serum CA125 diagnosis (P <0.05). CONCLUSION: The β-h CG level of serum and urine as well as the serum levels of AFP and CA125 in the second trimester may accurately reflect the existence of placental dysfunction. The diagnosis of β-h CG in blood and urine is more accurate.