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本文报告1978年3月～1981年3月现场试验伤寒菌株 Ty21a 口服疫苗预防伤寒病的效果,并测定其安全性及稳定性。对象是伤寒流行区(埃及的阿历山大市)6～7岁的小孩,共分3组进行对照观察。第1组口服疫苗组,共16,486人,每次服疫苗稀释液20～30ml,隔日1次,共3次;第2组安慰剂组,共15,902人,服奶粉与糖制成的溶液,用量及服法如第1组;第3组不服药组,共25,628人。试验后连续随访3年。凡原因不明的发热超过3天者,均住院进行伤寒病的细菌学及血清学检查。如血液培养阳性则证实为伤寒病;有伤寒的临床症状,血培养阴性但大便培养阳性或血清伤寒“O”及“H”抗体效价≥1:400者可能为伤寒病。
This article reports from March 1978 ~ March 1981 on-site typhoid strain Ty21a oral vaccine in the prevention of typhoid fever, and to determine the safety and stability. The object is typhoid epidemic (Alexandria, Egypt) 6 to 7-year-old child, divided into three groups were observed. The first group of oral vaccine group, a total of 16,486 people, each taking vaccine dilution 20 ~ 30ml, every other day, a total of 3 times; the second placebo group, a total of 15,902 people served milk powder and sugar solution, the amount of The method of taking clothes is as in group 1; the group 3 is not taking medication and a total of 25,628 people. After the trial for 3 years. Where unexplained fever more than 3 days, were hospitalized for bacteriology and serological examination of typhoid fever. If the positive blood culture was confirmed as typhoid fever; clinical symptoms of typhoid, blood culture negative but stool culture positive or serum typhoid “O” and “H” antibody titers ≥ 1: 400 may be typhoid fever.