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目的探讨ＰＣＮＡ在原发性胆囊癌的表达及意义。方法３４例原发性胆囊癌，８例胆囊腺瘤和１０例慢性胆囊炎石蜡包埋标本，用ＳＰ免疫组织化学方法测定。结果ＰＣＮＡ在原发性胆囊癌、胆囊腺瘤和慢性胆囊炎中的阳性表达指数分别为４３．７５±２１．７３％、７．９８±５．１９％和４．３１±２．１５％，原发性胆囊癌ＰＣＮＡ指数显著高于胆囊良性病变（Ｐ＜０．０１）。低分化腺癌ＰＣＮＡ指数显著高于高、中分化者（Ｐ＜０．０１）。结论原发性胆囊癌的发生发展与细胞的异常增殖有关，ＰＣＮＡ可作为胆囊癌预后的重要指标
Objective To investigate the expression and significance of PCNA in primary gallbladder carcinoma. Methods 34 cases of primary gallbladder carcinoma, 8 cases of gallbladder adenoma and 10 cases of chronic cholecystitis paraffin-embedded specimens were determined by SP immunohistochemistry. Results The positive expression indexes of PCNA in primary gallbladder carcinoma, gallbladder adenoma and chronic cholecystitis were 43.75±21.73%, 7.98±5.19% and 4.31±2.15%, respectively. The PCNA index of primary gallbladder carcinoma was significantly higher than that of gallbladder benign lesions (P<0.01). The PCNA index of poorly differentiated adenocarcinoma was significantly higher than that of high and moderately differentiated (P<0.01). Conclusion The occurrence and development of primary gallbladder carcinoma is related to the abnormal proliferation of cells. PCNA may be an important prognostic indicator of gallbladder cancer.