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目的:探讨重症急性胰腺炎(SAP)肺损伤的发病机制及黄芪注射液对其的相关作用。方法:SD大鼠72只随机分为SAP组、假手术组(对照组)、黄芪组,通过逆行胰胆管注射3.5%牛磺胆酸钠建立重症胰腺炎肺损伤大鼠动物模型,检测血清淀粉酶、超氧化物歧化酶(SOD)、丙二醛(MDA)含量和肺组织湿/干比值及胰腺、肺组织病理情况。结果:与SAP组比较,黄芪组血淀粉酶和肺组织湿/干比值及血MDA含量下降,而血SOD含量升高(P<0.05);黄芪组胰腺和肺组织损伤减轻。结论:黄芪注射液可通过抗氧化作用而对SAP肺损伤起到防治作用。
Objective: To investigate the pathogenesis of lung injury in severe acute pancreatitis (SAP) and the related role of Huangqi Injection. METHODS: Seventy-two SD rats were randomly divided into SAP group, sham operation group (control group) and Huangqi group. The rat model of severe pancreatitis and lung injury was established by retrograde injection of 3.5% sodium taurocholate into the pancreaticobiliary duct to detect serum starch. Enzyme, superoxide dismutase (SOD), malondialdehyde (MDA) content and wet/dry ratio of lung tissue, pathological conditions of pancreas and lung tissue. RESULTS: Compared with SAP group, the serum amylase and wet/dry ratios of lung tissue and blood MDA content in Astragalus membranaceus group decreased, while the SOD level in blood increased (P<0.05). The damage of pancreas and lung tissue in Astragalus group decreased. Conclusion: Huangqi injection can prevent and treat SAP lung injury through antioxidation.