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目的探讨顺铂周疗联合放化疗在中晚期宫颈癌患者中的应用效果。方法于2009年2月至2010年2月,采用随机数字表法将中晚期宫颈癌患者94例分为对照组和研究组,每组47例;对照组采用紫杉醇联合放疗同步顺铂3周的治疗方案,研究组采用紫杉醇联合放疗同步顺铂周疗的治疗方案。比较两组患者疗效、5年生存率及不良反应。结果对照组与研究组总有效率比较差异无统计学意义(P>0.05);对照组5年生存率为46.8%,研究组5年生存率为51.1%,组间比较差异无统计学意义(P>0.05);两组患者不良反应发生率比较差异有统计学意义(P<0.05)。结论采用放疗同步化疗周疗方案治疗宫颈癌,疗效与3周疗法相当,不良反应较3周疗法少,值得推广应用。
Objective To investigate the effect of cisplatin combined with radiotherapy and chemotherapy in patients with advanced cervical cancer. Methods From February 2009 to February 2010, 94 patients with advanced cervical cancer were divided into control group and study group by random number table method, with 47 cases in each group. The control group was treated with paclitaxel combined with radiotherapy for 3 weeks Treatment options, the study group using paclitaxel combined with radiotherapy cisplatin treatment of peripheral treatment. The curative effect, 5-year survival rate and adverse reactions of the two groups were compared. Results There was no significant difference in the total effective rate between the control group and the study group (P> 0.05). The 5-year survival rate was 46.8% in the control group and 51.1% in the study group. There was no significant difference between the two groups P> 0.05). There was significant difference in the incidence of adverse reactions between the two groups (P <0.05). Conclusions The treatment of cervical cancer by radiotherapy combined with weekly chemotherapy has the same curative effect as 3-week therapy and less adverse reactions than 3-week therapy, which is worthy of promotion.