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目的：一定程度上区分孤束核（ＮＴＳ）内ＧＡＢＡＡ和ＧＡＢＡＢ受体对血压调节的作用。方法：ＮＴＳ微注射、ＮＴＳ损毁及电刺激下丘脑防御反应区，记录血压和心率。结果：ＧＡＢＡＡ受体拮抗剂荷包牡丹碱能逆转ＧＡＢＡ摄取抑制剂３－哌啶甲酸引起的血压升高，ＧＡＢＡＢ受体拮抗剂ＣＧＰ３５３４８则不能；谷氨酸使蝇蕈醇所致的血压升高小幅度下降，对ＧＡＢＡＢ受体激动剂引起的血压升高无明显影响；刺激下丘脑防御反应区引起的血压升高能被ＮＴＳ部位注射荷包牡丹碱所阻断，ＧＡＢＡＢ受体拮抗剂ＣＧＰ３５３４８不能。结论：ＮＴＳ部位的ＧＡＢＡＡ和ＧＡＢＡＢ受体在对心血管功能的调控方面存在差异，这些差异可能是由于ＧＡＢＡＡ受体主要存在于突触后膜，ＧＡＢＡＢ受体主要存在于突触前膜所造成的
Objective: To some extent differentiate the effects of GABAA and GABAB receptors on blood pressure regulation in the nucleus tractus solitarius (NTS). Methods: NTS microinjection, NTS damage and electrical stimulation of the hypothalamic response area, recording blood pressure and heart rate. Results: GABAA receptor antagonist bicuculline could reverse the increase of blood pressure induced by 3-piperidinecarboxylic acid, an inhibitor of GABA uptake, but not GABAB receptor antagonist CGP35348. Glutamate increased the blood pressure of muscimol The decrease of amplitude had no significant effect on the increase of blood pressure induced by GABAB receptor agonist. The increase of blood pressure induced by stimulation of hypothalamic defensive reaction zone could be blocked by bicuculline injection at NTS site, and GABAB receptor antagonist CGP35348 could not. CONCLUSIONS: There are differences in the regulation of cardiovascular function between GABAA and GABAB receptors in NTS, which may be due to the GABAA receptor mainly in the postsynaptic membrane and the GABAB receptor mainly in the presynaptic membrane