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目的:探讨体素内不相干运动扩散加权成像(introvoxel incoherent motion diffusion weighted imaging,IVIM-DWI)技术在早期高血压患者脑灌注中的应用价值,以指导临床及早进行干预治疗.方法:对36例早期高血压患者(高血压组)和14例健康志愿者(对照组)分别行常规MRI(包括轴位T2WI、T1WI、T2FLAIR)、时间飞跃法磁共振血管成像(time of flight magnetic resonance angiography,TOF-MRA)及IVIM-DWI技术扫描,测量2组受检者相关脑区的灌注相关弥散系数D*值和灌注分数f值,使用独立样本t检验对所得数据进行比较.结果:高血压组在脑豆状核、丘脑、额上回、枕叶、胼胝体膝部及侧脑室后角白质区域的D*值和f值均低于对照组,差异有统计学意义(P0.05).结论:IVIM-DWI技术能够发现早期高血压患者的脑灌注异常情况,对高血压脑病的防治具有重要价值.“,”Objective To explore the value of intra-voxel incoherent motion diffusion weighted imaging(IVIM-DWI)in brain perfusion of early hypertensive patients. Methods Totally 36 hypertensive patients and 14 volunteers were recruited and scanned using routine MRI sequences including axial T2WI, T1WI, T2FLAIR, TOF-MRA and IVIM-DWI sequence. Perfusion-related diffusion coefficient (D*) values and perfusion fraction (f) values in various regions were measured separately.The independent sample t test was used to analyze the data.Results Compared with the volunteers,both D*values and f values in lenticular nucleus,thalamus,superior frontal gyrus,occipital lobe,genu of corpus callosum(CC)and posterior horns of periventricular WM, were found to be lower (P0.05).Conclusion IVIM-DWI has the ability to detect subtle brain perfusion abnormalities at early stages of hypertension.It has an important value to the prevention and treatment of hypertensive encephalopathy.