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目的探讨中国汉族人环氧化酶2的单核苷酸多态性位点及单元型与动脉粥样硬化缺血性脑卒中的关系。方法对626名缺血性脑卒中患者和604名健康者检测环氧化酶2的两个多态位点:-1195G/A和8473T/C,并对每个基因位点和两个位点的单元型进行分析。结果8473T/C位点的基因型TC在疾病组中明显增多(经混杂因素校正后,OR=1.329,95%CI=1.028-1.719),单元型A-1195C8473的比率在疾病组较对照组高,Logistic回归分析显示带有单元型A-1195C8473的个体更容易患缺血性脑卒中(经混杂因素校正后,OR=1.372,95%CI=1.070-1.760)。结论在汉族人环氧化酶2的基因型TC(8473T/C位点)和单元型A-1195C8473可能是脑梗塞的遗传易感因素。
Objective To investigate the association between single nucleotide polymorphisms (SNPs) of cyclooxygenase 2 (SNP) and haplotypes in ischemic stroke of atherosclerosis in Chinese Han population. Methods Two polymorphic sites of cyclooxygenase 2 (-1195G / A and 8473T / C) were detected in 626 ischemic stroke patients and 604 healthy subjects. The haplotypes were analyzed. Results Genotype TC of 8473T / C locus increased significantly in the disease group (OR = 1.329, 95% CI = 1.028-1.719 after confounding factors). The percentage of haplotype A-1195C8473 in the disease group was higher than that in the control group Logistic regression analysis showed that individuals with haplotype A-1195C8473 were more susceptible to ischemic stroke (OR = 1.372, 95% CI = 1.070-1.760, adjusted for confounding factors). Conclusion The genotype TC (8473T / C locus) and haplotype A-1195C8473 of cyclooxygenase 2 in Chinese may be genetic predisposition to cerebral infarction.