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目的:进一步提高对炎性假瘤的认识及诊断水平,进一步探讨本病变的性质及组织发生。方法:对63例原诊断肺炎性假瘤的HE切片逐个进行组织学和临床病理的回顾性复习研究,结合文献资料进行了组织学分型、命名,并对其中10例肺硬化性血管瘤应用免疫组化LSAB法进行了6种抗体(EMA、SMA、KP-1、波形蛋白、CgA、S-100)的检测。结果:将肺炎性假瘤分为三型:硬化性血管瘤样型;浆细胞肉芽肿型;纤维组织细胞瘤样型。炎性假瘤是一种以间质成分增生为主的混合性炎性增生。主要增生细胞为各种间质细胞、上皮细胞;神经内分泌细胞也有不同程度增生。结论:根据细胞成分的多样性、生长方式上无包膜以及生物学行为上具有一定的自限性均符合是炎性假瘤,而不是真性肿瘤。
Objective: To further improve the understanding and diagnosis of inflammatory pseudotumor, to further explore the nature of this lesion and its occurrence. Methods: The histological and clinicopathological retrospective study of 63 cases of pulmonary inflammatory pseudotumor were retrospectively reviewed. The histological type and nomenclature were combined with the literature data, and 10 cases of pulmonary sclerosing hemangioma were immunized Six kinds of antibodies (EMA, SMA, KP-1, vimentin, CgA, S-100) were detected by histochemical LSAB method. Results: Pneumonia pseudotumor was divided into three types: sclerosing hemangioma type; plasma cell granuloma type; fibrous histiocytoma type. Inflammatory pseudotumor is a mixed interstitial hyperplasia-based inflammatory hyperplasia. The main proliferation of cells for a variety of interstitial cells, epithelial cells; neuroendocrine cells also have different degrees of proliferation. CONCLUSIONS: According to the diversity of cellular components, there is no envelope on the growth pattern and certain self-limiting biological behavior are in line with inflammatory pseudotumor rather than true tumor.