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自1990年 Reyes 等分离出戊型肝炎病毒(HEV)的 cDNA 后,我们能应用血清学和分子生物学的方法,诊断甲、乙、丙、丁、戊五型病毒性肝炎,但是仍有相当部分的病毒性肝炎的病原无法确定。美国 NIH 对98例输血后肝炎(PTH)进行了肝炎病原学的调查,其中12例(12%)病原不明.在欧洲,13%～50%的急性肝衰竭由甲型肝炎,乙型肝炎和丁型肝炎引起,而15%～20%的病例虽被认为是病毒性的,却无法发现与已知五型肝炎有关。Fagan 等几年前用电子显微镜对20例因非甲非乙型肝炎引起急性肝衰竭而行肝移植的病人进行了研究,在9个切除下的原始肝脏中发现有囊膜病毒样颗粒(togavirus-like particles),其中5例在移植肝中重新发现这种病毒颗粒,而在其它原因引起的急性肝衰竭的肝脏中,从未发现这种病毒颗粒.囊膜病毒
Since Reyes et al. Isolated the cDNA of hepatitis E virus (HEV) in 1990, we can apply serological and molecular biological methods to diagnose hepatitis A, B, C, D and E. However, Some of the pathogens of viral hepatitis can not be determined. In the United States, 98 cases of posthepatitic hepatitis (PTH) were analyzed for hepatitis etiology by the NIH, of which 12 (12%) were unknown. In Europe, 13% to 50% of acute liver failure is caused by hepatitis A, Hepatitis D causes, while 15% to 20% of cases are considered viral, but can not be found with the known five types of hepatitis. A few years ago, Fagan et al. Studied 20 patients undergoing liver transplantation for acute liver failure caused by non-A, non-B hepatitis by using an electron microscope. In nine of the resected primary liver, togavirus -like particles, of which 5 cases rediscovered the virus particles in the grafted liver and never found in the liver of acute liver failure caused by other causes. The enveloped virus