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目的探讨新辅助化疗对IB2~IIB期宫颈癌患者的治疗效果,评价其临床疗效。方法选取2012年10月—2014年7月衡阳市中心医院收治的58例晚期宫颈癌患者,随机分为两组,各29例。对照组患者进行常规手术治疗,观察组患者在新辅助化疗后给予手术治疗,比较两组患者的临床疗效及手术效果。采用SPSS 18.0统计学软件进行统计分析,计量资料采用t检验;计数资料采用χ2检验,P<0.05为差异有统计学意义。结果观察组患者的治疗总体有效率为93.1%(27/29),高于对照组患者的治疗总体有效率72.4%(21/29),差异有统计学意义(P<0.05);两组患者的手术中各项指标(手术时间、术中出血量)比较,观察组优于对照组,差异有统计学意义(P<0.05)。结论新辅助化疗能够提高IB2~IIB期宫颈癌患者的治疗有效率,减少手术时间,提高手术成功率,具有很好的临床价值。
Objective To investigate the effect of neoadjuvant chemotherapy on patients with stage IB2 ~ IIB cervical cancer and evaluate its clinical efficacy. Methods Fifty-eight patients with advanced cervical cancer who were treated in Hengyang Central Hospital from October 2012 to July 2014 were randomly divided into two groups (n = 29 in each group). The patients in the control group were treated by conventional surgery. The patients in the observation group were given surgical treatment after neoadjuvant chemotherapy. The clinical curative effect and operation effect of the two groups were compared. SPSS 18.0 statistical software for statistical analysis, measurement data using t test; count data using χ2 test, P <0.05 for the difference was statistically significant. Results The overall effective rate was 93.1% (27/29) in the observation group and 72.4% (21/29) in the control group, with significant difference (P <0.05). The two groups of patients (Operation time, intraoperative blood loss), the observation group was superior to the control group, the difference was statistically significant (P <0.05). Conclusion Neoadjuvant chemotherapy can improve the treatment efficiency of patients with cervical cancer of stage IB2 ~ IIB, reduce the operation time and improve the success rate of surgery, which has good clinical value.