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本文使用胶束色谱法研究了某些非甾体抗炎药的疏水性。检查了胶束色谱保留值与文献logPow的相关性。观察了表面活性剂SDS浓度的影响。对于胶束洗脱剂,logK’与logPow的相关好于k与logPow.与logk’w((甲醇—水为洗脱剂得到的外推容量因子)相比,logk’与logPow的相关性较好。logKMw(胶束—水结合常数)或logK’o(胶束浓度为零时的保留因子)与logPow也存在着线性相关。结果表明在药物定量构效关系的研究中使用胶束色谱进行药物疏水性的定量测定是很有希望的。
In this paper, micellar chromatography was used to study the hydrophobicity of some NSAIDs. The correlation between micellar retention and literature logPow was examined. The effect of surfactant SDS concentration was observed. For micellar eluents, the correlation between logK ’and logPow is better than k and logPow, and the correlation between logk’ and logPow over logk ’w (extrapolated capacity factor from methanol-water as eluent) Good logKMw (micellar-water binding constant) or logK’o (retention factor at micellar concentration zero) is also linearly correlated with logPow The results show that the use of micellar chromatography in quantitative QSAR studies Quantitative determination of drug hydrophobicity is promising.