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目的探讨肿瘤标记物CEA和CA19-9的动态变化在评判结直肠癌肿手术治疗中的检测价值。方法选取瑞金市人民医院收治的52例结直肠癌为研究对象,作为观察组,将观察组患者按改良的Duke’s分级分为A、B、C、D4期,比较观察组患者与正常对照者(对照组)血清中CEA和CA19-9的浓度水平;同时,对观察组患者行根治切除原发肿瘤手术,回顾性分析结直肠各期患者手术前后血清CEA和CA19-9的浓度水平变化。结果近端结肠部位癌变与肿瘤低分化患者CEA与CA19-9水平均明显高于其他部位癌变患者与分化程度的患者,差异有统计学意义(P<0.05)。且结直肠癌A期与B期患者治疗后CEA水平显著降低,与治疗前相比,差异有统计学意义(P<0.05)。而C与D期患者CEA水平与治疗前相比,差异无统计学意义(P>0.05)。结论 CEA和CA19-9水平高低有利于结直肠肿瘤患者的早期诊断,其动态变化有利于评判治疗效果,是结直肠癌患者临床病情评估的重要指标。
Objective To investigate the detection of tumor markers CEA and CA19-9 dynamic changes in the evaluation of colorectal cancer surgery. Methods Fifty-two patients with colorectal cancer admitted to Ruijin People’s Hospital were enrolled in this study. Patients in the observation group were divided into A, B, C, and D stages according to the modified Duke’s classification. The patients in the observation group were compared with the normal controls Control group) serum CEA and CA19-9 levels; the same time, the observation group of patients underwent radical resection of the primary tumor surgery, retrospective analysis of colorectal cancer patients before and after surgery serum CEA and CA19-9 concentration levels. Results The levels of CEA and CA19-9 in patients with proximal colon cancer and poorly differentiated tumor were significantly higher than those in other patients with cancerous lesions and differentiation (P <0.05). The levels of CEA in patients with stage A and B colorectal cancer were significantly lower than those before treatment, the difference was statistically significant (P <0.05). There was no significant difference in CEA level between C and D patients before treatment (P> 0.05). Conclusion The high and low levels of CEA and CA19-9 are beneficial to the early diagnosis of colorectal cancer patients. The dynamic changes of CEA and CA19-9 are helpful to evaluate the therapeutic effect, which is an important index for assessing the clinical condition of patients with colorectal cancer.