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0引言NF-κB信号转导通路存在于多种细胞分化和增生过程中,通过控制多种细胞因子和生存基因表达,对恶性细胞的增殖、生存、转移和血管生成具有一定的促进作用[1-2],诸如在肺脏、肝脏、乳腺、皮肤、子宫等慢性炎症过程中恶性细胞的增殖显著增加[3]。i NOS和COX-2是NF-κB信号通?
0 Introduction NF-κB signal transduction pathway exists in a variety of cell differentiation and proliferation process, through the control of a variety of cytokines and survival gene expression on malignant cells proliferation, survival, metastasis and angiogenesis has a certain role in promoting [ -2], such as significant proliferation of malignant cells in chronic inflammatory processes such as lung, liver, breast, skin, and uterus [3]. i NOS and COX-2 is NF-κB signaling?