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一、产科DIC发病背景 1、血液凝固性亢进 从血栓弹性可以看出,孕妇有r和K短缩,ma增大,有特征性的血液凝固性亢进。 2、凝血因子增加 妊娠期除凝血因子Ⅷ外,几乎所有的凝血因子均增加。凝血因子增加的比例:抗凝血酶Ⅲ几乎没有增加,凝血系统处于优势状态。另外,可溶性纤维蛋白单体(SFMC)也增加。 3、纤溶活性低下 妊娠时,各脏器及血液的纤溶活性有降低倾向,即孕妇血液的优球蛋白溶解时间延长,血液中的激活物活性降低。另外,纤溶酶增加,纤溶酶原的消耗降低。血中纤维蛋白原降解产物(FDP)
First, the background of obstetric DIC 1, blood coagulation hyperthyroidism can be seen from the thrombus elasticity, pregnant women have shortened r and K, ma increased, characterized by blood coagulation hyperthyroidism. 2, clotting factor increase In addition to coagulation factor VIII during pregnancy, almost all of the coagulation factors were increased. Increase in the proportion of clotting factor: antithrombin Ⅲ almost no increase, the coagulation system in a dominant state. In addition, soluble fibrin monomer (SFMC) is also increased. 3, low fibrinolytic activity during pregnancy, fibrinolytic activity of various organs and blood have a tendency to decrease, that is, the blood of pregnant women, the euglobulin lysis time is prolonged, blood activator activity decreased. In addition, plasmin increases, reducing plasminogen consumption. Blood fibrinogen degradation products (FDP)