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多药耐药 (ｍｕｌｔｉｄｒｕｇｒｅｓｉｓｔａｎｃｅ ,ＭＤＲ)是急性白血病治疗失败的主要原因 ,在临床耐药研究中 ,ＭＤＲ表型与Ｐ 1 70(Ｐ糖蛋白 ,ｐ ｇｐ)表达有密切关系[1 ] 。多药耐药基因ｍｄｒ 1的表达产物 ｐ ｇｐ作为细胞膜上的药泵降低细胞内药物浓度导致耐药的机制
Multidrug resistance (MDR) is a major cause of failure in the treatment of acute leukemia. In the clinical drug resistance study, MDR phenotype is closely related to the expression of P 1 70 (P glycoprotein, p gp) [1]. Multidrug resistance gene mdr 1 expression product p gp as a drug pump on the cell membrane to reduce intracellular drug concentrations lead to drug resistance mechanism