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美国科学家在美国临床肿瘤协会会议上报告说,用感冒病毒治疗晚期癌症病人,可以使部分病人的病情得到缓解.大部分肿瘤细胞恶变的一个主要特征是细胞中的P53基因产生变异.美国休斯敦安德森癌症研究中心的研究人员先将引起感冒的腺病毒弱化,再将正常的P53基因注入这种病毒内,然后把这种改造过的腺病毒注射到20个晚期肺癌病人体内.5个半月后,在同时接受基因治疗和化疗的9个病人中,有8人病情稳定,l人肿瘤缩小;在只接受基因治疗的11个病人中,5人病情稳定,l人病情好转,5人病情恶化.加州奥尼克斯制药公司的研究人员做法有所不同,他们对腺病毒进行改造,使之不攻击正常细胞,但能识别并杀死缺乏P53基因的细胞.研究人员指出,从理论上讲,通过改造P53基因治疗癌症是治本之法,但究竟如何才能使这种方法产生最大疗效还需继续进行试验研究.
American scientists reported at the American Society of Clinical Oncology meeting that treating patients with advanced cancer with the cold virus can relieve the condition of some patients. One of the main features of the malignant transformation of most tumor cells is the mutation of the P53 gene in cells. Anderson, Houston, USA Researchers at the Cancer Research Center first weakened the cold-causing adenovirus, injected the normal P53 gene into the virus, and injected the modified adenovirus into 20 patients with advanced lung cancer. After five and a half months, Of the 9 patients who received both gene therapy and chemotherapy, 8 had stable disease and 1 had tumors shrinking. Of the 11 patients who received only gene therapy, 5 had stable disease, l had improved disease, and 5 had worsening disease. The researchers at California’s Onix Pharmaceuticals have a different approach. They modified the adenovirus so that it does not attack normal cells, but it can recognize and kill cells that lack the P53 gene. The researchers pointed out that theoretically, The transformation of P53 gene to treat cancer is a permanent cure. However, how to make this method produce the maximum effect still needs to continue experimental research.