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为探讨吸入一氧化氮（NO）对慢性缺氧性肺动脉高压的疗效及毒副作用，本文对正常（NN）组和慢性缺氧（HN）组大鼠吸入10～80ppmNO测定其血流动力学、血气和高铁血红蛋白（MetHb）变化，并对正常对照（NC）组、慢性缺氧对照（HC）组、NN组和HN组肺组织进行常规组织学及透射电镜观察。结果显示：HN组吸入NO后，肺动脉平均压（mPAP）和肺血管阻力（PVR）明显降低，且PVR降低程度与NO浓度呈效量依赖性，但吸人80PPmN时mPAP未较吸入40ppmNO时进一步降低；吸入NO对NN组和HN组体循环血流动力学、血气、MetHb含量及NN组mPAP和PVR均无明显影响；HE染色光镜和透射电镜显示HC和HN组肺的组织学及超微结构均呈慢性缺氧改变，但未发现NN组较NC组、HN组较HC组之肺组织学和超微结构有明显恶化改变。提示短时吸入低浓度NO对降肺动脉高压具有选择性、安全及无毒副作用等特点。
In order to investigate the therapeutic effect and side effects of inhaled nitric oxide (NO) on chronic hypoxic pulmonary hypertension, we measured the hemodynamics of 10 ~ 80ppmNO inhalation in normal and chronic hypoxic (HN) Blood gas and methemoglobin (MetHb). The lung tissues of normal control (NC) group, chronic hypoxic control (HC) group, NN group and HN group were observed by conventional histology and transmission electron microscopy. The results showed that the mean pulmonary arterial pressure (mPAP) and pulmonary vascular resistance (PVR) were significantly decreased in HN group after NO inhalation, and the reduction of PVR was dose-dependently dependent on the concentration of NO. However, when mPAP was inhaled at 80PPmN, NO, NO, nitric oxide (NO), nitric oxide (NO), nitric oxide (NO), nitric oxide The changes of chronic hypoxia and hypoxia were not observed in the NN group. Compared with the NC group and the HN group, the lung histology and ultrastructure of the HN group were significantly deteriorated. Prompted short-term inhalation of low concentrations of NO on pulmonary hypertension has a selective, safe and non-toxic side effects and so on.