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目的探讨血栓性血小板减少性紫癜 (TTP)的临床诊断和治疗方法。方法对 8例住院TTP患者临床资料进行回顾分析 ,同时复习相关文献。结果 8例患者均表现有微血管病性溶血性贫血、血小板减少及发热 ,6例分别有精神神经症状和肾脏损害。患者均接受血浆置换 (PE)治疗 ,其中 6例 (75 % )缓解。随访 5例 ,最长者达 6年 ,仅 1例复发 ,经PE治疗后再次缓解。结论TTP为多系统损伤的严重疾病 ,多可通过临床特征及实验室检查确诊 ,PE是目前治疗TTP最有效的首选方法
Objective To investigate the clinical diagnosis and treatment of thrombotic thrombocytopenic purpura (TTP). Methods The clinical data of 8 hospitalized TTP patients were retrospectively analyzed and the related literatures were reviewed. Results 8 patients showed microangiopathy hemolytic anemia, thrombocytopenia and fever, 6 patients had neurological symptoms and kidney damage respectively. All patients underwent plasma exchange (PE), of which 6 (75%) were relieved. Follow-up in 5 cases, the longest 6 years, only 1 case of recurrence after PE treatment again remission. Conclusions TTP is a serious disease with multiple system injuries and can be diagnosed by clinical features and laboratory tests. PE is the most effective and preferred method of treatment for TTP