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背景:肺炎链球菌是一种非同寻常的尚不被十分了解的在幼小婴儿中引起侵袭性细菌性疾病的原因。本项研究目的在于测定7价肺炎球菌结合疫苗(PCV7)对苏格兰和威尔士年龄小于90天的婴儿中侵袭性肺炎球菌病(IPD)的影响,并且描述了PCV7引入后这种疾病的临床特征。方法:在PCV7引入前,IPD的发病率在小于90天的婴儿中为13.0/100000(90%置信区间,12.0~14.0),并且PCV7血清型占血清分型分离物的44%(154/349)。PCV7的引入使PCV7 IPD降低了83%(95%CI,60%~
Background: Streptococcus pneumoniae is an unusual and unrecognized cause of invasive bacterial disease in young infants. The aim of this study was to determine the impact of the 7-valent pneumococcal conjugate vaccine (PCV7) on invasive pneumococcal disease (IPD) in infants younger than 90 days in Scotland and Wales and to describe the clinical features of this disease following the introduction of PCV7. Methods: Prior to introduction of PCV7, the incidence of IPD was 13.0 / 100000 (90% confidence interval, 12.0-14.0) in infants younger than 90 days and PCV7 serotype accounted for 44% of serotyped isolates (154/349 ). The introduction of PCV7 reduced PCV7 IPD by 83% (95% CI, 60% ~)