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目的：了解医学大专生健康危险行为现状及与负性生活事件的关系，为降低其危险行为发生率提供科学依据．方法采用分层随机整群抽样方法抽取576名云南医学大专生，用一般情况问卷、健康危险行为问卷和青少年生活事件量表对其进行调查，采用描述性统计、卡方检验和Logistic回归分析．结果云南医学大专生吸烟率为3.1%，饮酒率为4.9%，拒食率为39.6%，打架率为13.5%，上网率为26.4%，滥用药物率为3.1%；不同性别、不同专业学生健康危险行为发生率差异统计学意义（P＜0.05）；Logistic回归分析结果示：负性生活事件总评分对饮酒率（OR=1.017，P＜0.05）、拒食率（OR=1.018，P＜0.05）、打架率（OR=1.021，P＜0.05）、上网率（OR=1.025，P＜0.05）和成瘾药物滥用率（OR=1.025，P＜0.05）存在正性影响．人际关系因子对饮酒率（OR=1.162，P＜0.05）、拒食率（OR=1.102，P＜0.05）和药物滥用率（OR=1.260，P＜0.05）有正性影响；受惩罚因子对打架率有正性影响（OR=1.144，P＜0.05），对饮酒率有负性影响（OR=0.891，P＜0.05）；学习压力因子对打架率有正性影响（OR=1.143，P＜0.05）；丧失因子对打架率有负性影响（OR=1.144，P＜0.05）．结论负性生活事件是云南医学大专生危险行为的影响因素，且不同因子的影响方式存在差异．“,”Objective To analyze the situation of health-risk behaviors of the students in specialty medical science college of Yunnan and its relationship with negative life events, and provide scientific evidence for lowering the occurrence rate of health-risk behaviors. Methods The stratified randomised cluster-sampling method was used to select 576 students of specialty medical science college, and the occurrence rate of health-risk behaviors and life events conditions were estimated by Youth Health-Risk Behavior Questionnaire and Adolescents Self-Rating Life Events Checklist. Descriptive statistic analysis, Chi-square test and Logistic regression analysis was used to analyze the data. Results Among the students of specialty medical science college in Yunnan, the rate of smoking was 3.1%,the rate of drinking was 4.9%,the rate of food refusal was 39.6%, the rate of fighting was 13.5%,the rate of obsessed with the internet was 26.4%, and the rate of substance abuse was 3.1%. There were significant differences between the students of different genders (P<0.05) or specialities (P<0.05) . Logistic regression analysis showed total score of negative life events had positive influence on drinking (OR=1.017,P<0.05), foodrefusal (OR=1.018,P<0.05), fighting (OR=1.021,P<0.05), obsessed with the internet (OR=1.025, P<0.05), substance abuse (OR=1.025, P<0.05) . The factor of interpersonal relationship had positive influence on drinking (OR=1.162,P<0.05), food refusal (OR=1.102,P<0.05), substance abuse (OR=1.260, P<0.05) . The factor of punished had positive influence on fighting (OR=1.144, P<0.05), and had negative influence on drinking (OR=0.891, P<0.05) . The factor of study pressure had positive influence on fighting (OR=1.143, P<0.05), and the factor of loss had negative influence on fighting (OR=1.144, P<0.05) . Conclusion Negative life events are influencing factors for health-risk behaviors of the students in specialty medical science college of Yunnan, and there is difference on the way that the factor of life events influencing health-risk behaviors.