与健康受试者或疟疾恢复期患者比较，奎宁对急性感染恶性疟疾患者的药动学呈现较慢的清除率及较长的消除半衰期等变化，而在疟疾急性感染期间出现肝功能失调可能是产生这些变化的原因。为此，本文研究了奎宁对急性肝炎息者、肝炎恢复期患者和健康受试者的药动学。给6名肝、肾功 Compared with healthy subjects or patients with convalescent malaria, quinine showed a slower clearance rate and longer elimination half-life in patients with acute infection of falciparum malaria, and liver dysfunction may occur during the acute malaria infection Is the reason for these changes. For this reason, this paper studies the pharmacokinetics of quinine in patients with acute hepatitis, patients with convalescent hepatitis and healthy subjects. To six liver, kidney function