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目的：探讨安定对学龄前儿童滴注氯胺酮的药代动力学影响。方法：１６例３．５～６岁择期手术学龄前儿童，随机分为两组，Ⅰ组为氯胺酮组，Ⅱ组为氯胺酮加安定组。用反向高效液相色谱法测定氯胺酮血药浓度，并计算药代动力学参数。结果：两组房室模型均拟合为二房室开放模型、药代动力学参数：Ⅰ组Ｔ１／２α＝（０．１５±０．０４）ｈ，Ｔ１／２β＝（２．８４±０．４４）ｈ，ＣＬ＝（０．３４±０．０６）Ｌ／ｋｇ·ｈ，Ｖｄ＝（０．６６±０．２９）Ｌ／ｋｇ。Ⅱ组Ｔ１／２α＝（０．１４±０．０６）ｈＴ１／２β＝（３．９２±０．５２）ｈ，ＣＬ＝（０．２６±０．０５）Ｌ／ｋｇ·ｈ，Ｖｄ＝（０．６５±０．０７）Ｌ／ｋｇ。结论：安定使氯胺酮清除半衰期延长，清除率降低
Objective: To investigate the effects of diazepam on pharmacokinetics of ketamine in preschool children. Methods: Totally 16 preschoolers aged from 3.5 to 6 years were randomly divided into two groups. Group Ⅰ was ketamine group, group Ⅱ was ketamine plus diazepam group. Ketamine concentrations were determined by reverse-phase high performance liquid chromatography and pharmacokinetic parameters were calculated. Results: The two atrioventricular models were fitted to open two - compartment model. The pharmacokinetic parameters were as follows: group Ⅰ T1 / 2α = (0.15 ± 0.04) h, T1 / 2β = (2.84 ± 0. 44) h, CL = (0.34 ± 0.06) L / kg · h, Vd = (0.66 ± 0.29) L / kg. In group Ⅱ, T1 / 2α = (0.14 ± 0.06) hT1 / 2β = (3.92 ± 0.52) h, CL = (0.26 ± 0.05) L / kg · h, Vd = 0.65 ± 0.07) L / kg. Conclusion: Diazepam prolongs the elimination half-life of ketamine and reduces the clearance rate