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硝苯吡啶(nifedipine)是一治疗和预防各种心绞痛和高血压的有效新药。亦用于左心功能不全的心衰患者。我厂生产的硝苯啶胶丸系以硝苯吡啶为原料制成的软胶囊制剂,它具有生物有效利用度好的优点。现将本品的制备、含量测定和临床应用报道如下。一、软胶囊的制备1.稀释剂的选择药物稀释剂的选择是软胶囊的关键,它关系到分剂量的准确和制剂的稳定性,并直接影响药物的安全有效性。本品单剂量为每丸5mg,
Nifedipine is an effective new drug for the treatment and prevention of various angina and hypertension. Also for left heart failure in patients with heart failure. I plant the production of nifedipine capsules with nifedipine as raw material made of soft capsule formulations, it has the advantage of good bioavailability. Now the preparation of this product, determination and clinical application reported as follows. First, the soft capsule preparation 1. The choice of diluent The choice of drug diluent is the key to soft capsule, which is related to the accuracy of sub-dose and stability of the preparation, and directly affect the safety and efficacy of drugs. This product single dose of 5mg per pill,