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目的探讨丙型肝炎病毒（ＨＣＶ）感染的发病机制．方法应用酶联免疫吸附法、间接免疫荧光法、放射免疫法测定了慢性ＨＣＶ感染者６６例，慢性ＨＢＶ感染者３７例和正常对照３９例的血清抗ＧＯＲ抗体（抗ＧＯＲ）、抗核抗体（ＡＮＡ）、抗甲状腺球蛋白抗体及抗甲状腺微粒体抗体（ＴＧＡ／ＴＭＡ）．结果ＨＣＶ感染者抗ＧＯＲ，ＡＮＡ，ＴＧＡ／ＴＭＡ的阳性率较正常对照组均明显增高（５３０％ｖｓ５１％，χ２＝２４６４９，Ｐ＜００１；４２４％ｖｓ２６％，χ２＝１９４９０，Ｐ＜００１；１３６％ｖｓ０％，χ２＝５８２０，Ｐ＜００１）；与慢性ＨＢＶ感染者比较，慢性ＨＣＶ感染者抗ＧＯＲ，ＡＮＡ阳性率显著增高（χ２＝２０５５０，Ｐ＜００１；χ２＝４５１３，Ｐ＜００５）．慢性ＨＣＶ感染中，血清谷丙转氨酶（ＡＬＴ）增高者抗ＧＯＲ阳性率及ＡＮＡ阳性率显著高于ＡＬＴ正常者（６５０％ｖｓ３４６％，χ２＝６１１０；５２５％ｖｓ２６９％，χ２＝５９１０，Ｐ＜００５），ＨＣＶＲＮＡ阳性者抗ＧＯＲ阳性率显著高于阴性者（χ２＝４８１０，Ｐ＜００５）．结论上述结果说明ＨＣＶ感染者存在自身免疫反应，这种自身免疫反应与病毒复制?
Objective To investigate the pathogenesis of hepatitis C virus (HCV) infection. Methods Serum anti-GOR antibody (anti-GOR), anti-nuclear antibody (anti-GOR antibody) and anti-nuclear antibody ANA), anti-thyroglobulin antibodies and anti-thyroid microsomal antibodies (TGA / TMA). Results The positive rates of anti-GOR, ANA and TGA / TMA in HCV infection were significantly higher than those in normal control group (530% vs 5.1%, χ2 = 24649, P <001; 424% vs2 6%, χ2 = 19490, P <001; 136% vs0%, χ2 = 5820, P <001). Compared with patients with chronic HBV infection, chronic HCV infection were resistant to GOR, ANA The positive rate was significantly higher (χ2 = 20550, P <001; χ2 = 4513, P <005). In chronic HCV infection, the anti-GOR positive rate and ANA positive rate of serum ALT were significantly higher than those with normal ALT (650% vs 346%, χ2 = 6110; 525% vs26 9%, χ2 = 5910, P <005). The positive rate of anti-GOR in HCVRNA positive patients was significantly higher than that in negative patients (χ2 = 4810, P <005). Conclusion The above results indicate that there is an autoimmune reaction in HCV-infected patients. Is this autoimmune reaction complicated by virus replication?