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目的：研究钙调素拮抗剂亲脂区与亲水区之间连接链最佳的距离。方法：采用Fibonacci寻找法设计并合成了不同长度侧链的1，2－二苯乙烯类钙调素拮抗剂。结果：它们的拮抗活性表明，随着连接亲水部分氨基与亲脂苦环部分的碳链的增长，其活性增强。分子图形学研究显示，随着碳链的增长，氨基与钙调素Glu84，87的羧基的距离缩短，静电相互作用增强，拮抗剂与钙调素的结合能增加，并在碳链个数7左右达到一个极值。结论：在1，2-二苯乙烯类钙调素拮抗剂中，连接亲脂区与亲水区的脂肪链的碳原子的最佳个数在7左右。
Objective: To study the optimal distance between the lipophilic region of the calmodulin antagonist and the hydrophilic region. Methods: Fibonacci searching method was used to design and synthesize stilbene antagonists with different length of side chain. Results: Their antagonistic activity shows that their activity increases with the increase of the carbon chain linking the hydrophilic amino group to the lipophilic bitter ring moiety. Molecular graph shows that with the increase of carbon chain, the amino group is shortened from the carboxyl group of calmodulin Glu84,87, the electrostatic interaction is enhanced, and the binding of antagonist and calmodulin can increase, and the number of carbon chains 7 Around to reach an extreme value. CONCLUSION: In the stilbene antagonist, the optimal number of carbon atoms in the fatty chain connecting the lipophilic region and the hydrophilic region is about 7.