论文部分内容阅读
目的观察高剂量的半夏对使用SPS方法建立的PTSD模型大鼠的行为学影响。方法将40只Wistar大鼠随机分为4组,分别为正常组、模型组、高剂量半夏组、阿普唑仑组,每组10只。将模型组、高剂量半夏组、阿普唑仑组采用SPS方法进行造模,于造模后一天分别给予相对应的药物或生理盐水进行灌胃,连续灌胃7天后进行旷场实验和强迫游泳实验的行为学检测。结果模型组与正常组相对比,模型组在旷场实验中穿格次数、运动总距离、最大运动距离均减少(P<0.01),强迫游泳实验中僵立次数与时间明显增高(P<0.01)。高剂量半夏组与模型组相对比,高剂量半夏组在旷场试验中穿格次数、运动总距离、最大运动距离均升高(P<0.05),强迫游泳实验中僵立次数与时间减少(P<0.05)。阿普唑仑组与模型组相对比,阿普唑仑组在旷场试验中穿格次数、运动总距离距离均升高(P<0.05),强迫游泳实验中僵立次数与时间减少(P<0.05)。高剂量半夏组与阿普唑仑组相比各项指标无明显差别(P>0.05)。结论高剂量半夏对PTSD模型大鼠焦虑和恐惧相关行为学指标具有良好改善作用,其作用效果与阿普唑仑相似。
Objective To observe the effect of high dose of Pinella on behavior of PTSD model rats established by SPS method. Methods Forty Wistar rats were randomly divided into four groups: normal group, model group, high dose Banxia group and alprazolam group, with 10 rats in each group. The model group, high-dose Pinellia group, alprazolam group using SPS method for modeling, one day after the model were given the corresponding drug or saline for gavage, continuous gavage 7 days after the open-field experiments and Behavioral testing of forced swimming test. Results Compared with the normal group, the number of wears, the total distance of movement and the maximum distance of movement in the model group were significantly decreased (P <0.01) ). Compared with the model group, the high-dose group of Pinellia ternata increased the numbers of wears, the total distance of exercise and the maximum distance of exercise in the open-field test (P <0.05) Decrease (P <0.05). Alprazolam group compared with the model group, alprazolam group in open-field test in the number of wears through the grid, the total distance away from the movement were increased (P <0.05), forced swimming test in the number of freezing and time decreased (P <0.05). Compared with the alprazolam group, there was no significant difference between the high-dose group and the alprazolam group (P> 0.05). Conclusion High dose of Pinellia has a good effect on anxiety and fear-related behavioral parameters in PTSD rats, and its effect is similar to that of alprazolam.