答:双氢克尿塞是氯散疾的衍生物,氯散疾杂环上的双键为二个氢原子所飽和,性質与氯散疾相似,利尿效能約为氯散剂十倍,而利鉀作用小。此药是一种强效的非汞利尿药,主要为排除体内氯化物及鈉,对肾小管无毒性,双腎性水肿可以应用。双氢克尿塞,是有效的碳酸酐酶抑制剂,增加鈉及氯化物自尿中排出,也能促进重碳酸盐和鉀的排出。作者应用腎性水肿,不論是急性腎炎、慢性腎炎等均有显著的利尿作用,一般用药后2—4小时出現疗效,持續12—48小时完全排出。 A: Hydrochlorothiazide hydrochlorothiazide is a derivative of chlorine, chlorine ring chlorine atoms on the double bond is saturated with two hydrogen atoms, the nature of chlorine and similar disease, diuretic efficacy of chlorine powder about ten times, and the role of potassium is small. This drug is a potent non-mercury diuretic, mainly to exclude the body of chloride and sodium, non-toxic renal tubules, renal edema can be applied. Hydrochlorothiazide, an effective carbonic anhydrase inhibitor, increases the excretion of sodium and chloride from the urine and also promotes the excretion of bicarbonate and potassium. The application of renal edema, whether acute nephritis, chronic nephritis and so have significant diuretic effect, the general effect of 2-4 hours after treatment, sustained 12-48 hours completely discharged.