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动脉粥样硬化(Atherosclerosis,AS)是严重威胁人类健康的主要心血管疾病之一,由于它是一种血管的病变,而血管与血液成分有着密切的关联,所以最近二十年来有关血液成分与AS的发生之问的联系得到广泛关注。血小板则是血液细胞成分中与AS发病关系最受重视的一种成分。 Carstair(1965)、Moore(1976)、Friedman(1977)、Harker(1976)等实验结果均表明:一定数量的m小板是动脉平滑肌细胞增生和纤维斑块形成所必需的物质基础;血小板的聚集、释放功能被药物抑制后,动脉平滑肌增生也受到抑制。此外,许多实验室都证明:心绞痛、心肌梗塞病人血小板对诱聚剂的敏感性增高,血小板寿命缩短,血中β-TG、
Atherosclerosis (AS) is one of the major cardiovascular diseases that pose a serious threat to human health. Because it is a kind of vascular lesion and the blood vessels are closely linked with blood components, the relationship between blood components and The connection between the occurrence of AS has drawn wide attention. Platelets are the most important component of the relationship between blood cell components and AS pathogenesis. The experimental results of Carstair (1965), Moore (1976), Friedman (1977) and Harker (1976) showed that a certain number of m platelets are the necessary material basis for the proliferation of arterial smooth muscle cells and the formation of fibrous plaques; the aggregation of platelets , Release of the drug is inhibited, arterial smooth muscle hyperplasia is also inhibited. In addition, many laboratories have proved: angina pectoris, myocardial infarction patients with increased sensitivity of the platelet inhibitor, shortened platelet life, blood β-TG,