过去十年中,细菌对抗生素的抗药性处于高潮期,因此不论对医院或一般开业的医师来讲,治疗严重感染成为问题。菌类对当代抗微生物药物不断增加抗药性的一个重要因素是某些细菌细胞有防护其本身的能力,这是通过一些酶来实现的,这些酶攻击了抗生素薄弱的β-内酰胺键,从而破坏了药物的活性。然而,产生各种β-内酰胺酶的细菌现在也成为易受攻击的部分。首先,较新的β-内酰胺抗生素,例如第三代头孢菌素或第四代 Over the past decade, bacteria have been at the climax of resistance to antibiotics, so treating serious infections is a problem for hospitals or for general practitioners. An important factor for fungi to increase their resistance to contemporary antimicrobials is that certain bacterial cells have the ability to defend themselves by enzymes that attack the weak β-lactam bonds of antibiotics and thereby Disrupted the activity of the drug. However, bacteria that produce various beta-lactamases are now also vulnerable. First, newer beta-lactam antibiotics, such as third generation cephalosporins or fourth generation