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21只新西兰兔经结扎胆总管制成肝硬变动物模型，而后随机分为胸外营养一ICT组（n＝10）及肠外营养一MCT/LCT组（n＝11），两组所含非蛋白热卡及氮量均相等，观察肝硬变时兔组织内肉毒碱含量的变化以及在肠外营养支持中应用ICT和MCT/后体内代谢的改变，并与正常对照组（n=10）比较。结果显示：肝硬变时兔血中甘油三酯、胆固醇及肉毒碱的含量均明显升高（P＜0．05），在场外营养第7天，LCT组甘油三脂、肉毒均高于MCT/LCT组（P＜o．01）；各组肝脏、心肌、骨骼肌及小肠中肉毒碱含量明显下降（P＜0．01）；肝内脂肪含量LCT组高于MCT/LCY组（P＜0．05）。本研究结果提示，MCT/LCT乳剂因其非肉毒碱依赖性，血中清除快，肝内脂肪存积少，可能是应用于肝硬变时更为理想的能源。
Twenty-one New Zealand rabbits underwent ligation of the common bile duct to establish an animal model of cirrhosis, and then were randomly divided into a thoracotomy-ICT group (n = 10) and a parenteral nutrition-MCT / LCT group Non-protein heat card and nitrogen content were the same, to observe the changes of carnitine content in rabbit liver tissue after liver cirrhosis and the use of ICT and MCT / pituitary metabolism in parenteral nutrition support, and with the normal control group (n = 10) Compare. The results showed that the content of triglyceride, cholesterol and carnitine in cirrhotic rabbits were significantly increased (P <0.05). On day 7 of the extracorporeal nutrition, triglyceride and botulinum In MCT / LCT group (P <0.01), carnitine content in liver, myocardium, skeletal muscle and small intestine decreased significantly (P <0.01); the intrahepatic fat content in LCT group was higher than that in MCT / LCY group (P <0.05). Our results suggest that MCT / LCT emulsion may be an ideal energy source for liver cirrhosis because of its non-carnitine dependence, fast blood clearance, and low intrahepatic fat storage.