论文部分内容阅读
目的 研究鼻硬结病的临床病理特点 ,探讨鼻硬结病的发病及组织损伤的机理。方法 以 33例鼻硬结病患者的组织标本为研究对象 ,全部用组织化学Warthin Starry(W S)染色 ,5例进行透射电镜观察。结果 经W S染色在肉芽肿内的Mikulicz细胞内检测出大量短棒状鼻硬结杆菌 ,细胞外偶见。电镜显示Mikulicz细胞内出现大量吞噬泡 ,将细胞器挤到一侧 ,粗面内织网及溶酶体很少。绝大多数鼻硬结杆菌寄宿于Mikulicz细胞的吞噬泡内 ,数量多达十几条 ,细菌壁有一层高电子密度的粗、细颗粒 ,显示胞内菌的特点。结论 鼻硬结杆菌可能是一种兼性胞内菌 ,具有抵抗巨吞噬细胞降解 ,能在巨吞噬细胞内大量繁殖和传播的能力 ,而肉芽肿形成和纤维化是造成组织损伤的主要原因。
Objective To study the clinicopathological features of nasal cirrhosis and to explore the mechanism of the pathogenesis of nasal cirrhosis and tissue damage. Methods Tissue samples from 33 patients with nasal cirrhosis were studied, all stained with Warthin Starry (Ws), and 5 cases were observed by transmission electron microscopy. Results A large number of short rod-shaped Corynebacterium nosocomials were detected in the cells of Mikulicz granuloma via W staining. Electron microscopy revealed a large number of phagocytic vacuoles in Mikulicz cells, squeezing the organelles to one side, and there were few microglia and lysosomes. The vast majority of C. nasalis colonizes the phagocytic vacuoles of Mikulicz cells, as many as a dozen, and the bacterial walls have a layer of coarse, fine particles of high electron density that characterizes intracellular bacteria. CONCLUSION: Corynebacterium nosocomialis is a facultative intracellular bacterium, which has the ability to resist the degradation of macrophages and multiply and spread in macrophages. However, granuloma formation and fibrosis are the main causes of tissue damage.