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目的 探讨影响男性垂体泌乳素瘤疗效的因素。方法 回顾性分析38例男性泌乳素瘤患者的临床、病理及随诊资料,探讨影响其预后的因素。结果 治愈缓解16例,进步12例,无效10例。采用手术、放疗和/或药物综合治疗者较单纯手术者治愈缓解率显著高。术前PRL<1000μg/L者疗效较PRL>1000μg/L者显著好;年龄大于30岁者疗效较30岁以下者显著好。肿瘤大小及侵袭性程度和预后无关。结论 男性垂体泌乳素瘤对各种治疗方式的敏感性相对较差,手术、药物和/或放射治疗的综合治疗方式仍是其最有效的治疗方法,术前血清PRL水平和年龄是判断其预后的良好指标。
Objective To explore the factors affecting the efficacy of male pituitary prolactinoma. Methods Retrospective analysis of 38 cases of prolactinoma in patients with clinical, pathological and follow-up data to explore the factors that affect the prognosis. Results cured remission in 16 cases, improved in 12 cases, ineffective in 10 cases. Patients treated with surgery, radiotherapy and / or drug therapy had significantly higher cure-remission rates than those treated with surgery alone. Preoperative PRL <1000μg / L were more effective than PRL> 1000μg / L; those over 30 years of age were significantly better than those under 30 years of age. Tumor size and aggressiveness have nothing to do with prognosis. Conclusions Male pituitary prolactinoma is relatively poorly sensitive to various treatment modalities. Comprehensive treatment of surgery, drugs and / or radiation therapy remains the most effective treatment. The preoperative serum PRL level and age are the indicators of prognosis Good indicator.