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目的探讨肺癌病人免疫功能变化的原因和机理．方法用体外培养的方法观察25例肺癌病人血清对正常淋巴细胞转化的影响，以高效液相凝胶过滤法测定肺癌病人血清中免疫抑制物的分子量。结果肺癌病人血清能显著抑制正常小鼠淋巴细胞转化，其抑制强度与肺癌的TNM分期有正相关关系（P＜0．01），而与肺癌病人的年龄和肺癌的病理类型无关．结论肺癌病人血清中存在免疫抑制物，它的产生与肿瘤的存在和发展有密切的关系．
Objective To explore the cause and mechanism of the change of immune function in lung cancer patients. Methods The effect of serum from 25 patients with lung cancer on the conversion of normal lymphocytes was observed by in vitro culture method. The molecular weight of the immunosuppressants in lung cancer patients was determined by high performance liquid-gel filtration. Results The serum of lung cancer patients could significantly inhibit the lymphocyte transformation of normal mice, and the inhibition intensity was positively correlated with the TNM stage of lung cancer (P<0.01), but not with the age of lung cancer patients and the pathological type of lung cancer. Conclusion There are immunosuppressants in the serum of patients with lung cancer. Its production is closely related to the existence and development of tumors.