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加利利链霉菌思文变种产生的蒽环类抗生素3082A、B和Y经酸水解,所得到的配基3082Z被各种波谱数据鉴定为带有7S、9R、10R手性中心的阿克拉霉酮。水解产物中糖的种类被薄层层析结果所确定;各分子中糖的个数(分析~1H-和~(13)C-NMR谱等)、糖的连接顺序(分析FAB-MS等)、糖的相互连接位置及苷键构型(分析~1H-NMR数据等)均由分析比较它们的理化特性和波谱数据得到结论。该研究表明,3082A、B和Y分别与AclacinomycinA_1、B_1和Y_1化学结构相同。
The anthracycline antibiotics 3082A, B and Y produced by Streptomyces griseus Sven were acid-hydrolyzed and the resulting ligand 3082Z was identified by various spectroscopic data as aclacinomycin with a 7S, 9R, 10R chiral center . The types of sugars in the hydrolyzate are determined by the results of thin layer chromatography; the number of sugars in each molecule (analysis of ~ 1H- and ~ (13) C-NMR spectra, etc.), the order of linkage of sugars (analysis of FAB-MS, etc.) , The position of glycosylation and the configuration of glycosidic bond (~ 1H-NMR data) were analyzed by comparing their physical and chemical properties and spectral data. This study shows that 3082A, B and Y have the same chemical structure as AclacinomycinA_1, B_1 and Y_1, respectively.